Microphysiological systems (MPS) comprise a number of bioengineering breakthroughs that reproduce organ architecture and function in vitro. Fueled by stem-cell technologies, a broad variety of especially human models and test systems have emerged, which make relevant experimental tools broadly available through international and multidisciplinary collaborations. Conference series are a key tool to form a community and accelerate scientific developments, their implementation and global harmonization. They provide an overview on the state-of-the-art in such dynamic and diverse fields, enabling transfer learning. A global conference on MPS was identified by opinion leaders in the field as a key step forward in the maturation and harmonization of the area. 40+ international organizations and companies have teamed up for a series of annual MPS World Summits to present the latest scientific achievements, discuss the advances and challenges, and enable communication between young and newly interested scientists and pioneers of the MPS field.